报  告 人: Jun Lu, Ph.D., Assistant Professor

    Department of Genetics, Yale University School of Medicine

报告主题: Principles of microRNA processing in cancer

报告时间: 2018年7月2日（星期一）上午10:30

报告地点: 独墅湖校区703楼唐仲英血液学研究中心502学术报告厅

简  介：Dr. Lu received his PhD from Boston University (Biochemistry) in 2003. After his postdoctoral fellowship at Broad Institute of MIT and Harvard, Cambridge, MA, Dr. Lu received his faculty as a research assistant professor, at Department of Genetics, Yale University School of Medicine, New Haven, CT in 2009 and he was a core member of Yale Stem Cell Center. He then obtained a faculty position as an assistant director at Cell Preparation and Analysis Core, Yale Cooperative Center of Excellence in Hematology. Dr. Lu’s research has been focusing on the Principles of microRNA processing in cancer.

Representative Publications:

1. Shangqin Guo, Haitao Bai, Cynthia Megyola, Stephanie Halene, Diane S. Krause, David T. Scadden and Jun Lu. Complex oncogene dependence in miR-125a-induced myeloproliferative Neoplasm. PNAS, 109(41):16636-16641, 2012 

2. Brian D. Adams, Shangqin Guo, Haitao Bai, Yanwen Guo, Cynthia Megyola, Jijun Cheng,
Kartoosh Heydari, Changchun Xiao, E. Premkumar Reddy, and Jun Lu. An In Vivo Functional Screen Uncovers miR-150-Mediated Regulation of Hematopoietic Injury Response. Cell Reports,2(4):1048-1060, 2012 

3. Jessica Bockhorn, Rachel Dalton, Chika Nwachukwu, Simo Huang, Aleix Prat, Kathy Yee, YaFang Chang, Dezheng Huo, Yujia Wen, Kaitlin E. Swanson, Tyler Qiu, Jun Lu, Seo Young Park, M. Eileen Dolan, Charles M. Perou, Olufunmilayo I. Olopade, Michael F. Clarke, Geoffrey L. Greene, Huiping Liu. MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nature Communications, 4:1393, 2013 

4. A Molecular Chipper Technology for CRISPR sgRNA Library Generation and Functional
Mapping of Noncoding Regions. Jijun Cheng*, Christine Roden, Wen Pan, Shu Zhu, Anna Baccei, Xinghua Pan, Tingting Jiang, Yuval Kluger, Sherman Weissman, Shangqin Guo, Richard Flavell, Ye Ding and Jun Lu. Nature Communications, 7:11178, 2016 

5. Jun Liu, Bo Guo, Zhuo Chen, Nayi Wang, Michelina Iacovino, Jijun Cheng, Christine Roden, Wen Pan, Sajid Khan, Suning Chen, Michael Kyba, Rong Fan, Shangqin Guo and Jun Lu. miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. Blood, 129(11):1491-1502, 2017