课题组长：陈苏宁
课题组主要关注白血病、骨髓增生异常综合征、骨髓增殖性肿瘤等血液肿瘤的新细胞和分子遗传学标志的筛选及临床意义阐释，应用多组学技术及体内外研究模型探讨多种新分子异常的致病机制研究和靶向治疗价值。相关课题获美国白血病淋巴瘤协会和国际华氏巨球蛋白血症基金会资助，此外还获得国家自然科学基金面上项目、863计划子项目、江苏省杰出青年基金项目、江苏省社会发展重大项目、江苏省特聘教授等资助。课题组在Blood、Leukemia、Cell Reports、Haematologica 等刊物发表SCI论文50 余篇，荣获国家科技进步奖二等奖（2016）一项，荣获江苏省科技进步奖一等奖（2009、2015）、教育部科技进步一等奖（2015）、中华医学科技奖二等奖（2015）、江苏医学科技奖一等奖（2015）、苏州市科技进步奖一等奖（2009）。
代表性论文 Selected publications：
1. Liu T, Wen L, Yuan H, Wang Y, Yao L, Xu Y, Cen J, Ruan C, Wu D, Chen S. Identification of novel recurrent CPSF6-RARG fusions in acute myeloid leukemia resembling acute promyelocytic leukemia. Blood. 2018 Apr 19;131(16):1870-1873.
2. Wen L, Xu Y, Yao L, Wang N, Wang Q, Liu T, Pan J, Cen J, Zhou H, Miao M, Shao YW, Wang X, Wang X, Ruan C, Wu D, Chen S. Clinical and molecular features of acute promyelocytic leukemia with variant retinoid acid receptor fusions. Haematologica. 2018 Sep 20. [Epub ahead of print]
3. Yao L, Wen L, W a n g N, Liu T, Xu Y, Ruan C, Wu D, Chen S. Identification of novel recurrent STAT3-RARA fusions in acute promyelocytic leukemia lacking t(15;17)(q22;q12)/PML-RARA. Blood. 2018 Feb 22;131(8):935-939.
4. Zhang T, Xu Y, Pan J, Li H, Wang Q, Wen L, Wu D, Sun A, Chen S. High frequency of RUNX1 mutation in myelodysplastic syndrome patients with whole-arm translocation of der(1;7)(q10;p10). Leukemia. 2017 Oct;31(10):2257-2260.
5. Ping N, Sun A, Song Y, Wang Q, Yin J, Cheng W, Xu Y, Wen L, Yao Hong, Ma L, Qiu H, Ruan C, Wu D, Chen S. Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemia. Leukemia 2017 31(1):195-202.
6. Cheng J, Guo S, Chen S, Mastriano SJ, Liu C, D'Alessio AC, Hysolli E, Guo Y, Yao H, Megyola CM, Li D, Liu J, Pan W, Roden CA, Zhou XL, Heydari K, Chen J, Park IH, Ding Y, Zhang Y, Lu J. An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis. Cell Rep. 2013;5(2):471-81.
7. Wu L, Xu Y, Wang Q, Ruan C, Drexler HG, Wu D, MacLeod RA, Chen S. High frequency of cryptic chromosomal rearrangements involving the LMO2 gene in T-cell acute lymphoblastic leukemia. Haematologica. 2015 Jun;100(6):e233-6.
8. Wang Q, Dong S, Yao H, Wen L, Qiu H, Qin L, Ma L, Chen S. ETV6 mutation in a cohort of 970 patients with hematologic malignancies. Haematologica. 2014 Oct;99(10):e176-8.
9. Ping N, Qiu H, Wang Q, Dai H, Ruan C, Ehrentraut S, Drexler HG, MacLeod RA, Chen S. Establishment and genetic characterization of a novel mixedphenotype acute leukemia cell line with EP300-ZNF384 fusion. J Hematol Oncol. 2015 Aug 21;8(1):100.
10. Yao H, Pan J, Wu C, Shen H, Xie J, Wang Q, Wen L, Wang Q, Ma L, Wu L, Ping N, Zhao Y, Sun A, Chen S. Transcriptome sequencing reveals CHD1 as a novel fusion partner of RUNX1 in acute myeloid leukemia with t(5;21)(q21;q22). Mol Cancer. 2015 Apr 11;14:81.