武艺  

联系信息

江苏省苏州市工业园区仁爱路199号703号楼503室
苏州大学唐仲英血液学研究中心
电话86-512-65880877/0899转3503
传真：86-512-65880929
Email: wuy@suda.edu.cn

教育背景：

1982年-1987年 河北医科大学 医学专业 学士
1991年-1994年 河北医科大学 内科学专业 硕士
1997年-2002年 日本山梨大学医学院 生物化学专业 博士
2002年-2005年 美国新泽西医学院 分子生物学专业 博士后

工作经历：

2005年-2008年 美国Temple大学血栓研究中心 助理教授
2009年-至今 苏州大学唐仲英血液学研究中心 教授

研究领域：

1. 血栓形成的整合机制及抗血栓药物的新靶点的研发
本研究组从血小板的主要粘附受体的信号传导机制着手，力图发现新的调控血栓形成的靶分子，为揭示血栓形成的启动过程提供新的认识。
2. 血浆激肽释放酶-激肽系统（内源性凝血系统）在血管生物学与炎症中的作用
主要研究该系统及其活化产物对血管内皮及炎症反应的调控。所用的研究手段包括动物基因敲出模型，转基因动物模型，干细胞／祖细胞的体内归巢分化追踪及体外功能解析，分子生物学，细胞生物学，生物芯片分析，慢病毒基因转入体系等。
3. 凋亡细胞吞噬的分子机制及其在天然免疫中的作用
具体研究包括Gas6受体在巨噬细胞的吞噬功能和信号传导机制；uPAR在识别和吞噬凋亡细胞的分子机制及相关免疫调节功能；双链激肽原调理巨噬细胞吞噬的作用及其在的病理生理意义。

学术刊物任职：

Thrombosis Research 编委(2008 – present)
World Journal of Hematology 编委 (2012 – present)
Thrombosis Journal 副主编 (2013 – present）
Journal of Hematology & Thrombosis 编委 (2014 – present)
Journal of Clinical and Medical Case Reports 编委(2014 – present)
Cell Communication and Signaling 编委(2017 – present)

团队成员：

阳艾珍，博士，副研究员
赵珍珍，博士，博士后
博士 3名， 硕士 4 名

代表性成果：

1.Zhenzhen Zhao*#, Yucan Wang*, Aizhen Yang*, Yi Lu, Xiaofeng Yan, Meinan Peng, Yue Han, Chao Fang, Depei Wu#, Yi Wu#. A novel role for thioredoxin-related transmembrane protein TMX4 in platelet activation and thrombus formation. J Thromb Haemost, 2024 Sep 20:S1538-7836(24)00549-X.
2.A Yang*, L Lin, J Zhang, Y Wu#, Z Zhao#. A novel role for endoplasmic reticulum protein ERp72 in the pathogenesis of autoantibody-induced arthritis. Scand J Rheumatol. 2024 Jul 8:1-9.
3.Zhenzhen Zhao*#, Yixin Cheng, Yaqiong Zhang, Meinan Peng, Yue Han, Depei Wu, Aizhen Yang#, Yi Wu#. Transmembrane thiol isomerase TMX1 counterbalances the effect of ERp46 to inhibit platelet activation and integrin αIIbβ3 function. Research and Practice in Thrombosis and Haemostasis (2024).
4.Yaqiong Zhang*#, Aizhen Yang*, Zhenzhen Zhao#, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, and Yi Wu#. Protein disulfide isomerase is essential for spermatogenesis in mice. JCI insight. 2024;9(12):e177743. June 24, 2024.
5.Liang Gao*, Chao He*, Aizhen Yang*#, Haibin Zhou, Qingxian Lu#，Raymond B#. Birge, Yi Wu#. Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis. Cell Communication and Signaling. 2023 Aug 3;21(1):195. doi: 10.1186/s12964-023-01133-0.023.
6.Thrombin generation assay: the present and the future. Wu Y, Lu Y, Zhang J. Blood Coagulation & Fibrinolysis. 2022 Apr 20; 30:00–00.
7. A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice. Zhou J, Wu Y, Rauova L, Koma G, Wang L, Poncz M, Li H, Liu T, Fong KP, Bennett JS, Kunapuli SP, Essex DW. Blood. 2021 Nov 9;blood.2021012055.
8.The disulfide bond Cys2724-Cys2774 in the C-terminal cystine knot domain of von Willebrand factor is critical for its dimerization and secretion. Zhang Y, Chen F, Yang A, Wang X, Han Y, Wu D, Wu Y, Zhang J. Thromb J. 2021 Nov 27;19(1):94. (Corresponding author)
9.Wang B, Yan X, Chen F, Yang A, Lu Y, Wu Y. Plasma kallikrein contributes to ambient particulate matter-induced lung injury. Biochem Biophys Res Commun. 2019 Oct 20;518(3):409-415. (Corresponding author)
10.Zhao Z, Wu Y, Zhou J, Chen F, Yang A, Essex DW. The transmembrane protein disulfide isomerase TMX1 negatively regulates platelet responses. Blood. 2019 Jan 17;133(3):246-251. (Corresponding author)
11.Junsong Zhou, Aizhen Yang, Yucan Wang, Fengwu Chen, Zhenzhen Zhao, Viralkumar Davra, Katsue Suzuki-Inoue, Yukio Ozaki, Raymond Birge, Qingxian Lu and Yi Wu. Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation. Cell Commun Signal, 2018 Dec 12;16(1):98. (Corresponding author).
12.Yae Hu, Ruhong Yan, Ce Zhang, Zhichao Zhou, Meng Liu, Can Wang, Hong Zhang, Liang Dong, Tiantian Zhou, Yi Wu, and Ningzheng Dong, Qingyu Wu. HMGB1 from hypoxic trophoblasts promotes endothelial microparticle production and thrombophilia in preeclampsia. Arteriosclerosis, Thrombosis, and Vascular Biology. In press.
13.Chen F, Zhao Z, Zhou J, Lu Y, Essex DW, Wu Y. Protein disulfide isomerase enhances tissue factor-dependent thrombin generation. Biochem Biophys Res Commun. 2018 Jun 18;501(1):172-177. (Corresponding author)
14.B. Wang, A. Yang, Z. Zhao, C. He, Y. Liu, R.W. Colman, J. Dai, Y. Wu. Plasma kallikrein-kininogen pathway is critical in the pathogenesis of colitis in mice. Frontiers in Immunology. 2018 Feb 6;9:21. doi: 10.3389/fimmu.2018.00021. (Corresponding author).
15.A. Yang, F. Chen, C. He, J. Zhou, Y. Lu, J. Dai, R.B. Birge, Y. Wu. The pro-coagulant activity of apoptotic cells is mediated by interaction with Factor XII. Frontiers in Immunology, 2017,8:1188. Doi:10.3389/fimmu.2017.01188. (Corresponding author).
16.A. Yang, J. Zhou, B. Wang, R.W. Colman, J. Dai, W. Song, Y. Wu. A critical role for plasma kallikrein in autoantibody-induced arthritis. FASEB Journal. 2017;31(12):5419-5431. (Corresponding author).
17.J. Zhou, Y. Wu, F. Chen, L. Wang, L. Rauova, V.M. Hayes, M. Poncz, H. Li, T. Liu, J. Liu, D.W. Essex. The disulfide isomerase ERp72 supports arterial thrombosis. Blood. 2017;130(6):817-828. (Equal first author, co-corresponding author)
18.A. Yang, Z. Xie, B. Wang, R.W. Colman, J. Dai, Y. Wu. An essential role of high-molecular-weight kininogen in endotoxemia. Journal of Experimental Medicine. 2017;214(9):2649-2670. (Corresponding author).
19.J. Zhou, Y. Wu, L. Wang, L. Rauova, V.M. Hayes, M. Poncz, D.W. Essex. The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis. Journal of Clinical Investigation. 2015;125(12):4391-406. (Equal first author, co-corresponding author).
20.J. Nelson, Y. Wu,  X.H. Jiang,  R. Berretta,  S. Houser,  E. Choi,   J.F. Wang,   J. Huang, X.F. Yang, H. Wang. Hyperhomocysteinemia suppresses bone marrow CD34+/VEGFR2+ cells and inhibits progenitor cell mobilization and homing to injured vasculature - A role of β1 integrin in progenitor cell migration and adhesion. FASEB Journal 2015;29(7):3085-99.
21.Y. Wu. Contact pathway of coagulation and inflammation. Thrombosis Journal, 2015;13:17. doi: 10.1186/s12959-015-0048-y. eCollection 2015. (Invited review)
22.S. Kimani, K. Geng, C. Kasikara, G. Sriram, Y. Wu, and R.B. Birge. Phosphatidylserine (PS) and efferocytosis: Does defective PS recognition contribute to chronic inflammation and autoimmunity? Frontiers in Immunology, 2014;5:566. eCollection 2014. (Invited review)
23.J. Zhou, Y. Wu, L. Wang, L. Rauova, V.M. Hayes, M. Poncz and D.W. Essex. The disulfide isomerase ERp57 is required for fibrin deposition in vivo. Journal of Thrombosis and Haemostasis 2014;12(11):1890-7. (Equal first author)
24.K.Q. Nguyen, W.I. Tsou, D.A. Calarese, S.G. Kimani, S. Singh, S. Hsieh, Y. Liu, B. Lu, Y. Wu, S.J. Garforth, S.C. Almo, S.V. Kotenko, R.B. Birge. Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a Gain-of-Function capacity. Journal of Biological Chemistry 2014;289(37):25737-49.
25.X. Zhu, X. Zheng, Y. Wu. Cleaved high molecular weight kininogen stimulates JNK/FOXO4/ MnSOD pathway for induction of endothelial progenitor cell senescence. Biochemical Biophysical Research Communications. 2014;450(4):1261-5. (corresponding author).
26.N. Dong, T. Zhou, Y. Zhang, M. Liu, H. Li, X. Huang, Z. Liu, Y. Wu, K. Fukuda, J. Qin, Q. Wu. Corin mutations K317E and S472G from preeclamptic patients alert zymogen activation and cell surface targeting. Journal of Biological Chemistry. 2014;289(25):17909-16.
27.Z. Xie, J. Dai, A. Yang, Y. Wu. Role of bradykinin in the pathogenesis of anti-collagen antibodies-induced arthritis. Rheumatology 2014;53(7):1301-6. (corresponding author)
28.A. Yang, J. Dai, Z. Xie, R. W. Colman, Q. Wu, R.B. Birge and Y. Wu*. High molecular weight kininogen binds phosphatidylserine and opsonizes urokinase plasminogen activator receptor-mediated efferocytosis. Journal of Immunology 2014;192(9):4398-408. (corresponding author)
29.L. Wang, Y. Wu, J. Zhou, S.S. Ahmad, B. Mutus, N. Garbi, G. H?mmerling, J. Liu, and D.W. Essex. Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin. Blood 2013;122(22):3642-50. (equal first author, co- corresponding author)
30.X. Chen, Y. Zhang, Y. Wang, D. Li, L. Zhang, K. Wang, X. Luo, Z. Yang, Y. Wu, J. Liu. PDK1 regulates platelet activation and arterial thrombosis. Blood 2013;121(18):3718-26.
31.Y. Wu, S. Ahmad, J. Zhou, L. Wang, M.P. Cully, D.W. Essex. The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis. Blood 2012;119(7):1737-46.
32.J. Dai, A. Agelan, A. Yang, V. Zuluaga, D. Sexton, R.W. Colman, Y. Wu. A role for activation of the kallikrein-kinin system in the synovial recruitment of endothelial progenitor cells in arthritis. Arthritis & Rheumatism 2012;64(11):3574-82. (corresponding author).
33.Y. Wu. Regulation of endothelial progenitor cell function by plasma kallikrein-kinin system. In Vasculogenesis. ISBN 978-953-307-882-3. 2011. (corresponding author).
34.J. Dai, X. Zhu, M.C. Yoder, Y. Wu, R.W. Colman. Cleaved high molecular weight kininogen accelerates senescence of endothelial progenitor cells by induction of reactive oxygen species. Arteriosclerosis, Thrombosis and Vascular Biology 2011;31(4):883-889.(corresponding author).
35.R.W. Colman, Y. Wu, Y. Liu. Mechanisms by which cleaved kininogen inhibits endothelial cell differentiation and signalling. Thrombosis and Haemostasis. 2010;104(5):875-85.
36.Y. Wu, J. Dai, N.G. Schmuckler, M.C. Yoder, C.M. Overall, R.W. Colman. Cleaved kininogen inhibits endothelial progenitor cell differentiation via suppression of matrix metallopeptidase 2. Journal of Thrombosis and Haemostasis, 2010;8(1):185-93.(corresponding author).
37.V. D'mello, S. Singh, Y. Wu, and R.B. Birge. The urokinase plasminogen activator receptor promotes efferocytosis of apoptotic cells. Journal of Biological Chemistry 2009;284:17030-17038.
38.N. Tibrewal*, Y. Wu*, V. D’Mello, R. Akakura, B. Varnum, R.B. Birge. Autophosphorylation of docking site yr867 in Mertk allows for dissociation of multiple signaling pathways for the phagocytosis of apoptotic cells and down-modulation of LPS-inducible NF-?B transcriptional activation. Journal of Biological Chemistry 2008;283(6):3618-27. (*Equal first-author).
39.Y. Liu, I. Sainz, Yi Wu, R. Espinola, S. Hassan, R. Pixley, R.W. Colman. The inhibition of tube formation in a collagen-fibrinogen, three-dimensional gel by cleaved kininogen (HKa) and HK domain 5 (D5) is dependent on Src family kinases. Experimental Cell Research 2008;314(4): 774-788.
40.Y. Wu, V. Rizzo, Y. Liu, I. Sainz, N. Schmuckler, R.W. Colman. Kininostatin associates with caveolae and inhibits ?v?3 integrin activation in human umbilical vein endothelial cells. Arteriosclerosis, Thrombosis and Vascular Biology 2007;27(9):1968 -75. (corresponding author).
41.M.M. Khan, H.N. Bradford, I. Isordia-Salas, Y. Liu, Yi Wu, B. Ghebrehiwet, R.W. Colman. High molecular weight kininogen fragments stimulate the secretion of cytokines and chemokines through uPAR, Mac-1 and gC1qR in monocytes. Arteriosclerosis, Thrombosis and Vascular Biology 2006;26(10):2260-6.
42.Y. Wu, N. Tibrewal, R.B. Birge. Phosphatidylserine recognition by phagocytes: a view to a kill. Trends in Cell Biology 2006;16(4):189-97. (Invited review)
43.Y. Wu, S. Singh, M.M. Georgescu, R.B. Birge. A role for Mer tyrosine kinase in ?v?5 integrin-mediated phagocytosis of apoptotic cells. Journal of Cell Science 2005;118(3):539-553.
44.Y. Wu, N. Asazuma, K. Satoh, T. Takafuta, Y. Yatomi, M.C. Berndt, and Y. Ozaki. Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase. Blood 2003;101(9):3469-3476.
45.T. Ohmori, Y. Yatomi, Yi Wu, M. Osada, K. Satoh, and Y. Ozaki. Wheat germ agglutinin-induced platelet activation via platelet endothelial cell adhesion molecule-1: involvement of rapid phospholipase C-?2 activation by Src family kinases. Biochemistry 2001;40(43): 12992-13001.
46.Y. Wu, K. Inoue-Suzuki, K. Satoh, N. Asazuma, Y. Yatomi, M.C. Berndt, and Y. Ozaki. Role of Fc receptor ?-chain in platelet glycoprotein Ib-mediated signaling. Blood 2001;97(12):3836-3845.
47.K. Inoue, Y. Ozaki, M. Kainoh, Y. Shin, Y. Wu, Y. Yatomi, T. Ohmori, T. Tanaka, K. Satoh, and T. Morita. Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia/IIa: involvement of GPIa/IIa-associated Src and protein tyrosine phosphorylation. Journal of Biological Chemistry 2001;276:1643-1652.
48.Y. Wu, Y. Ozaki, K. Inoue, K. Satoh, T. Ohmori, Y. Yatomi, K. Owada. Differential activation and redistribution of c-Src and Fyn in platelets, assessed by MoAb specific for C-terminal tyrosine-dephosphorylated c-Src and Fyn. Biochimica et Biophysica Acta-Molecular Cell Research 2000;1497:27-36.
49.K. Inoue, Y. Ozaki, K. Satoh, Y. Wu, Y. Yatomi, Y. Shin, and T. Morita. Signal transduction pathways mediated by glycoprotein Ia/IIa in human platelets: comparison with those of glycoprotein VI. Biochemical Biophysical Research Communications 1999;256:114-120.
50.Y. Wu, L. Zuo, X. Cao. Flow cytometric measurement of platelet-bound fibrinogen in patients with coronary artery disease. Chinese Journal of Cardilogy 1996;24(3):200-202. (in Chinese)
51.Y. Wu. Platelet membrane glycoprtein aIIb-IIIa complex in cardiovascular disease. Foreign Medical Science - Cardiology 1996;23(3):151-153.(review, in Chinese)
52.Y. Wu, E. Du, H. Shan, J. Li, Y. Liu, X. Cao. Effect of Ticlopidine on platelet-bound fibrinogen in patients with myocardial infarction. Journal of Hebei Academy of Science 1996;13(3): 440-443. (in Chinese)
53.Y. Wu, X. Cao, J. Li, Y. Liu, L. Zuo, J Liu, J. Guo. Quantitative analysis of fibrinogen bound to platelet membrane in patients with thrombotic diseases. Hebei Medical Journal. 1993;15(6): 345-348. (in Chinese)