张磊
副教授，硕士生导师
联系信息
江苏省苏州市工业园区仁爱路199号703号楼B614室
苏州大学唐仲英医学研究院血液学研究中心
电话：86-512-65880899/3501
传真：86-512-65880929
邮箱：lzhang08@suda.edu.cn
教育背景：
2004年-2008年 兰州大学 生命科学与技术专业 学士
2008年-2011年 兰州大学 生物化学与分子生物学专业 硕士
2011年-2016年 同济大学 生物化学与分子生物学专业 博士
2016年-2018年 上海师范大学生命科学学院 师资博士后
2018年-2021年 Loyola University Chicago Medical Center 博士后
工作经历：
2021～ 至今 苏州大学 副教授
研究领域：
白血病干细胞自我更新相关的重要基因的功能鉴定，寻找治疗白血病的新靶点。
探究白血病的耐药机制，优化白血病的治疗方案。
团队成员：
研究生：麻荣耀，周晓楠，白洋
代表性成果（# equal contribution, * corresponding author）
1. Liu S#, Joshi K#, Zhang L#, Li W, Mack R, Runde A, Hagen PA, Barton K, Breslin P, Ji HL, Kini AR, Wang Z, Zhang J. (2024) Caspase 8 deletion causes infection/inflammation-induced bone marrow failure and MDS-like disease in mice. Cell Death & Disease, 15(4):278.
2. Liu S*, Tao Y, Wu S, Lin J, Fu S, Lu J, Zhang J, Fu B, Zhang E, Xu J, Wang J, Li L*, Zhang L*, Wang Z*. (2024) Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancer. Chinese Medicine, 19(1):7.
3. Zhang L, Luo H, Ni HM, Liu S, Xing H, Zhang J, Sellin M, Breslin S J P, Wei W, Denning MF, Small W Jr, Ding WX, Huang S, Zhang J. (2022) Ripk3 signaling regulates HSCs during stress and represses radiation-induced leukemia in mice. Stem Cell Reports, 17(6):1428-1441.
4. Joshi K#, Zhang L#, Breslin S J P, Kini AR, Zhang J. (2022) Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis. Journal of Experimental & Clinical Cancer Research, 41(1):294.
5. Mack R, Zhang L, Breslin P, Zhang J. (2021) The Fetal-to-Adult Hematopoietic Stem Cell Transition and its Role in Childhood Hematopoietic Malignancies. Stem Cell Reviews and Reports, 17(6):2059-2080.
6. Zhang L, Li J, Xu H, Shao X, Fu L, Hou Y, Hao C, Li W, Joshi K, Wei W, Xu Y, Zhang F, Dai S, Breslin S J PW, Zhang J, Zhang J. (2020) Myc-Miz-1 signaling promotes self-renewal of leukemia stem cells by repressing Cebpα and Cebpδ. Blood, 135(14):1133-1145.
7. Zhang L, Mack R, Breslin P, Zhang J. (2020) Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches. Journal of Hematology & Oncology, 13(1):157.
8. Li J#, Zhang L#, Yin L#, Ma N, Wang T, Wu Y, Wang M, Yang X, Xu H, Hao C, Li W, Wei W, Xu Y, Zhang F, Breslin P, Zhang J, Zhang J. (2019) In vitro Expansion of Hematopoietic Stem Cells by Inhibition of Both GSK3 and p38 Signaling. Stem Cells and Development, 15;28(22):1486-1497.
9. Wang JH#, Hu MJ#, Zhang L#, Shao XX, Lv CH, Liu YL, Xu ZG, Guo ZY. (2018) Exploring receptor selectivity of the chimeric relaxin family peptide R3/I5 by incorporating unnatural amino acids. Biochimie, 154:77-85.
10. Liu Y#, Zhang L#, Hu MJ, Liu YL, Xu ZG, Guo ZY. (2016) A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3. Archives of Biochemistry and Biophysics, 604:113-20.
11. Wu QP#, Zhang L#, Wang JH, Shao XX, Liu YL, Xu ZG, Guo ZY. (2016) Application of the novel bioluminescent ligand-receptor binding assay to relaxin-RXFP1 system for interaction studies. Amino Acids, 48(4):1099-107.
12. Zhang L, Song G#, Xu T, Wu QP, Shao XX, Liu YL, Xu ZG, Guo ZY. (2013) A novel ultrasensitive bioluminescent receptor-binding assay of INSL3 through chemical conjugation with nanoluciferase. Biochimie, 95(12):2454-9.