唐朝君  

联系信息

江苏省苏州市工业园区仁爱路199号703幢512室
苏州大学唐仲英血液研究中心
电话：0512-65880877-3509
传真：0512- 65882122
Email: zjtang@suda.edu.cn

教育背景：

2003/09–2008/12，重庆大学，生物医学工程，博士
1999/09–2003/06，重庆大学，生物工程，学士

工作经历：

2013/11-2022/06，苏州大学，唐仲英血液研究中心，副研究员
2017/01-2017/04，获ISTH“RTW”奖项，赴美国宾夕法尼亚大学技术交流
2009/01–2013/10，重庆大学，生物工程学院，讲师
2010/10-2012/05，法国国立医学与健康研究中心INSERM UMR949，法国斯特拉斯堡大学血液所，博士后

研究领域及内容/临床专攻领域及内容：

l 血小板活化和血栓形成
l 动脉粥样硬化
l 血流动力学

团队成员：

任丽洁，硕士，副研究员
卢穹宇，硕士，副理研究员
汪莹，博士研究生
倪浩釜，硕士研究生
王安妮，硕士研究生
张佳钰，硕士研究生

代表性成果：

发表论文：
[1] Chaojun Tang#*, Guona Chen#, Fan Wu#, Yiren Cao#, Fei Yang#, Tao You, Chu Liu, Menglu Li, Shuhong Hu, Lijie Ren, Qiongyu Lu, Wei Deng, Ying Xu, GuixueWang, Hanjoong Jo, Yonghong Zhang, Yi Wu, Brian A. Zabel, and Li Zhu*. Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes. Cardiovascular Research, 2023 Aug 7;119(9):1811-1824.
[2]Qiongyu Lu#, Ziting Liu#, Luyao Zhao#, Linru Xu, Chu Liu, Ling Li, Yiren Cao, Fengchan Li, Lili Wu, Lei Wang, Ting Chen, Tao You, Lijie Ren, Guixue Wang, Chaojun Tang*, Li Zhu*. Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis. Molecular Metabolism, 2023 Apr; 70: 101698.
[3]Fengchan Li, Zhen Zhu, Yun Du, Li Zhu, Chaojun Tang*. Preparation of a Single-Cell suspension from mouse carotid arteries for Single-Cell sequencing. August 29, 2023. jove.com/t/65863.
[4]Lin?Wen, Wenhua?Yan, Li?Zhu, Chaojun?Tang*, Guixue?Wang*. The role of?blood flow in?vessel remodeling and?its regulatory mechanism during?developmental angiogenesis. Cellular and Molecular Life Sciences, 2023, 80:162.
[5]Fengchan Li, Yun Du, Lei Hong, Ziting Liu, Kunmin Yan, Chu Liu, Zhen Zhu, Qiongyu Lu, Chaojun Tang*, and Li Zhu*. Single-cell transcriptional profiling of human carotid plaques reveals a subpopulation of endothelial cells associated with stroke incidences. J Cell Mol Med, 2022;26:3446-3459.
[6]Chaojun Tang#, Lei Wang#, Yulan Sheng, Zhong Zheng, Zhanli Xie, Fan Wu, Tao You, Lijie Ren, Lijun Xia, Changgeng Ruan, and Li Zhu*. CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice. Theranostics, 2021 Oct 3;11(20): 9791-9804.
[7]Fengchan Li#, Kunmin Yan, Lili Wu, Zhong Zheng, Yun Du, Ziting Liu, Luyao Zhao, Wei Li, Yulan Sheng, Lijie Ren, Chaojun Tang*, and Li Zhu*. Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow. Cell Death Discov 2021,7:180.
[8]Lei Hong #, Fengchan Li #, Chaojun Tang#, Ling Li, Lili Sun, Xiaoqiang Li*, and Li Zhu*. Semaphorin 7A promotes endothelial to mesenchymal transition through ATF3 mediated TGF-β2/Smad signaling. Cell Death Dis. 2020, 11(8):695.
[9]Lei Wang, Chaojun Tang*. Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives. Int J Mol Sci. 2020 Dec 21;21(24):9760.
[10]Lijie Ren, Tao You, Qing Li, Guona Chen, Ziting Liu, Xuefei Zhao, Yinyan Wang, Lei Wang, Yi Wu, Chaojun Tang*, Li Zhu*. Molecular docking-assisted screening reveals tannic acid as a natural protein disulphide isomerase inhibitor with antiplatelet and antithrombotic activities, Journal of Cellular and Molecular Medicine, 2020 Oct 30;24(24):14257-14269.
[11]Lijie Ren, Qing Li, Tao You, Xuefei Zhao, Xingshun Xu, Chaojun Tang*, Li Zhu*. Humanin analog, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules, Journal of Cellular and Molecular Medicine, 2020 Apr;24(8):4773-4783.
[12]Lijie Ren, Lei Wang, Tao You, Yifei Liu, Fan Wu, Li Zhu, Chaojun Tang*. Perivascular adipose modulates carotid plaque formation induced by disturbed flow in mice. J Vas Surg, 2019 Sep;70(3):927-936.e4
[13]Shuhong Hu, Yifei Liu, Tao You, Jack Heath, Linru Xu, Xiaowei Zheng, Aili Wang, Yinyan Wang, Fengchan Li, Fei Yang, Yiren Cao, Huayu Zhang, Janine M. van Gils, Anton Jan van Zonneveld, Hanjoong Jo, Qingyu Wu, Yonghong Zhang, Chaojun Tang*, Li Zhu*. Vascular Semaphorin 7A Upregulation by Disturbed Flow Promotes Atherosclerosis Through Endothelial β1 Integrin. Arterioscler Thromb Vasc Biol., 2018, 38(2):335-343.
[14]Chaojun Tang*,Yinyan Wang, Daoxi Lei, Lu Huang,Guixue Wang,Qinjia Chi, Yiming Zheng, Christian Gachet, Pierre H Mangin, Li Zhu. Standardization of a well-controlled in vivo mouse model of thrombus formation induced by mechanical injury. Thrombosis Research, 2016, 141:49-57
[15]Mathieu Schaff#, Chaojun Tang#, Eric Maurer, Catherine Bourdon, Nicolas Receveur, Anita Eckly, Béatrice Hechler, Christiane Arnold, Adèle de Arcangelis, Bernhard Nieswandt, Cécile V Denis, Olivier Lefebvre, Elisabeth Georges-Labouesse, Christian Gachet, Fran?ois Lanza, Pierre H Mangin*. Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation and arterial thrombosis. Circulation, 2013, 30;128(5):541-552.
[16]Eric Maurer#, Chaojun Tang#, Mathieu Schaff, Catherine Bourdon, Nicolas Receveur, Catherine Ravanat, Anita Eckly, Béatrice Hechler, Christian Gachet, Francois Lanza, Pierre H Mangin*. Targeting platelet GPIbβ decreases GPIb signaling, thrombin generation and prevents arterial thrombosis. Arterioscler Thromb Vascu Biol, 2013, 33(6):1221-1229.
[17]Pierre Henri Mangin, Chaojun Tang, Catherine Bourdon, Stéphane Loyau, Monique Freund, Béatrice Hechler, Christian Gachet, Martine Jandrot-Perrus*. A humanized GPVI mouse model to assess the antithrombotic efficacy of anti-GPVI agents. J Pharmacol Exp Ther, 2012, 341(1):156-163.
[18]Chaojun Tang, Xue Wu, Linqi Ye, Xiang Xie, Guixue Wang*. Effects of rotational culture on morphology, nitric oxide production and cell cycle of endothelial cells. Biocell, 2012, 36(3):97-103.
[19]Chaojun Tang, Guixue Wang*, Xue Wu, Zhenggong Li, Yang Shen, James C-M Lee, Qingsong Yu. The impact of vascular endothelial growth factor-transfected human endothelial cells on endothelialization and restenosis of stainless steel stents. Journal of Vascular Surgery, 2011, 53(2): 461-471.
[20]Chaojun Tang, Guixue Wang*, Yang Shen, Lijuan Wan, Li Xiao, Qin Zhang, Qingsong Yu, Lushan Liu, Guanbin Wen. A study on surface endothelialization of plasma coated intravascular stents. Surface & Coatings Technology, 2010, 204?:1487-1492.
[21]Chaojun Tang, Guixue Wang*, Yi Cao, Xue Wu, Xiang Xie, Li Xiao. Adhesion and endothelialization of endothelial cells on the surface of endovascular stents by the novel rotational culture of cells. Applied Surface Science, 2008, 255(2):315-319.

参编或参译著作：

[1]参译《威廉姆斯血液学》
[2]参译本专业国际权威书籍《Platelets》( ed. Alan D. Michelson) 第四版
[3]参编本专业国内书籍《基础血液学》

专利：

[1]唐朝君，朱力，任丽洁，卢穹宇。一种适用于体外细胞培养的锥板流体剪切力装置。国家实用新型专利，ZL202222181041.8，授权。
[2]王贵学，沈阳，张勤，唐朝君，俞青松。纳米涂层结合微孔化表面血管内支架改性方法。国家发明专利，CN200910103260.0，授权。
[3]王贵学，唐朝君，曹怡，吴雪。一种制备细胞支架的速度可调旋转培养装置。国家发明专利，CN200820097583.4，授权。
[4]王贵学，唐朝君，吴雪，邢才，谢翔，曹怡，肖丽。国家发明专利，CN200810069252.4，授权。
[5]王贵学，唐朝君。载双基因血管内支架及其制备方法。国家发明专利，CN200710078134.5，授权。
王贵学，张鹤，危当恒，唐朝君，刘芳，邓小燕。一种人造血管。国家发明专利，CN200610054134.7， 授权。

荣誉称号：

2015苏州市紧缺人才
2016江苏省血液学协同创新中心学术骨干

主要学术任职：

Stroke & Vascular Neurology (2022IF9.893)编委
《中国动脉硬化杂志》青年编委
中国病理生理学会动脉粥样硬化专业委员会青年委员和理事
中国生物材料学会材料生物力学分会委员