刘立民  

擅长疾病：

血液系统良恶性疾病诊治及造血干细胞移植，尤其擅长再生障碍性贫血、骨髓增生异常综合征、阵发性睡眠性血红蛋白尿症、纯红细胞再生障碍，溶血性贫血等各种血细胞减少症

个人简介

主任医师，医学博士，硕士生导师。主要从事各种良恶性血液病诊治及造血干细胞移植工作，尤其擅长红细胞疾病（如再生障碍性贫血、骨髓增生异常综合征、阵发性睡眠性血红蛋白尿症、纯红细胞再生障碍、溶血性贫血等各种贫血、血细胞减少症）的临床诊治和造血干细胞移植临床诊疗工作。参与制定《再生障碍性贫血诊断与治疗中国指南》、《中国成人自身免疫性溶血性贫血诊疗指南》、《阵发性睡眠性血红蛋白尿症诊断与治疗中国指南》、《阵发性睡眠性血红蛋白尿症克隆筛查及补体抑制剂治疗监测中国专家共识》、《中国输血依赖型β地中海贫血诊断与治疗指南》等多部诊疗指南（专家共识）。

科研情况

近年来相关研究成果多次在全国血液学会议、亚太骨髓移植会议（APBMT）、美国血液学年会（ASH）、欧洲血液学年会（EHA）及欧洲骨髓移植会议（EBMT）做大会口头发言及壁报交流，工作期间以第一作者及通讯作者在《Journal of Hematology & Oncology》、《Leukemia》、《Blood cancer journal》、《Frontiers in Immunology》、《Frontiers in Oncology》、《Bone Marrow Transplantation》、《Biology of Blood and Marrow Transplantation》等SCI及中华系列期刊发表学术论文60余篇。先后获江苏省科技进步一等奖、中华医学科技奖二等奖、江苏省新技术引进奖、市级科技进步奖多项，主持及参与省市级科研项目多项，参编参译学术专著4部。

学术任职

中华医学会血液学分会红细胞疾病学组全国委员
江苏高校血液学协同创新中心骨干人才
江苏省医学会血液学分会第七届、第八届青年委员
江苏省医学会血液学分会第八届红细胞疾病学组委员
江苏省医学会血液学分会造血干细胞移植学组第七届、第八届委员
苏州市医学会血液学分会委员
苏州市医学会血液学分会MDS/MPN学组副组长
苏州市医学会职业病分会委员

教育背景

(1) 2012-9至2015-6, 苏州大学, 血液病, 博士,
(2) 2006-9至2009-6, 兰州大学, 血液病, 硕士,
(3) 1994-9至1999-6, 徐州医学院, 临床医学, 学士

科研与学术工作经历

(1) 2020-12至现在, 苏州大学, 附属第一医院, 主任医师
(2) 2015-8至2020-12, 苏州大学, 附属第一医院, 副主任医师
(3) 2009-7至2012-8, 淮安市第二人民医院, 血液科, 主治医师
(4) 1999-8至2006-8, 江苏省沛县人民医院, 内科, 住院医师

研究领域

红细胞疾病及造血干细胞移植

取得研究成果和获得学术奖励情况

发表SCI文章
1. Limin Liu, Meiqing Lei, Rong Fu, Bing Han, Xin Zhao, Rongrong Liu, Yanming Zhang, Wenjing Jiao, Miao Miao, Fengkui Zhang, Liansheng Zhang, Depei Wu. Matched related transplantation versus immunosuppressive therapy plus eltrombopag for first-line treatment of severe aplastic anemia: a multicenter, prospective study. J Hematol Oncol 2022 Aug 12;15(1):105.
2. Limin Liu, Yanming Zhang, Wenjing Jiao, Huifen Zhou, Qingyuan Wang, Song Jin, et al. Comparison of efficacy and health-related quality of life of first-line haploidentical hematopoietic stem cell transplantation with unrelated cord blood infusion and first-line immunosuppressive therapy for acquired severe aplastic anemia. Leukemia, 2020;34(12):3359-3369.
3. Limin Liu, Shunqing Wang, Erlie Jiang, Yanming Zhang, Jianyong Li, Yuewen Fu, Meiqing Lei, Kailin Xu, Mingzhen Yang, Yinghao Lu, Miao Miao, Depei Wu. Haploidentical vs matched sibling donor transplant for paroxysmal nocturnal haemoglobinuria: A multicenter study.Blood Cancer Journal (2022) 12(6):92.
4. Liangliang Wu, Limin Liu, Xin Zhao, Ming Zhou, Andie Fu, Yuping Zhang , Wenrui Yang, Xiaowei Chen , Wenjian Mo , Caixia Wang, Yumiao Li , Shilin Xu , Shiyi Pan, Ruiqing Zhou , Fankai Meng, Fengkui Zhang, Depei Wu, Shunqing Wang. Unrelated donor hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for adults with severe aplastic anemia.Blood Cancer Journal (2024)14(1):37（并列第一作者）
5. Limin Liu, Miao Miao, Hailong He, Shunqing Wang, Yanming Zhang, Ailian Guo, Wenjing Jiao, Meiqing Lei, Yifeng Cai, Xiaohui Shangguan, Zefa Liu, Jinge Xu, Xiaoli Li, Liansheng Zhang, Depei Wu. Severe aplastic anemia patients with infection who received an allogeneic hematopoietic stem cell transplantation had a better chance: Long-term outcomes of a multicenter study. Frontiers in Immunology. 2022;13:955095.
6. Meiqing Lei , Yanming Zhang , Wenjing Jiao, Xiaoli Li , Huifen Zhou,Qingyuan Wang, Huiying Qiu, Xiaowen Tang, Yue Han, Chengcheng Fu, Zhengming Jin, Suning Chen, Aining Sun, Miao Miao, Limin Liu, Depei Wu. Comparison of Haploidentical Hematopoietic Stem Cell Transplant With or Without Unrelated Cord Blood Infusion in Severe Aplastic Anemia: Outcomes of a Multicenter Study. Frontiers in Immunology, 2022;13:912917.（并列通讯作者）
7. Limin Liu,Yanming Zhang, Wenjing Jiao, Huifen Zhou, Qingyuan Wang, Huiying Qiu, et al. Combination of haploidentical haematopoietic stem cell transplantation with an unrelated cord-blood unit in patients with severe aplastic anemia: a report of 146 cases. Bone Marrow Transplantation,2020;55(10):2017-2025.
8. Limin Liu,Yanming Zhang, Shan Liu, Huifen Zhou, Qingyuan Wang, Huiying Qiu, et al. Outcomes of conditioning with rabbit antithymocyte globulin and rituximab in haploidentical haematopoietic stem cell transplantation in patients with severe aplastic anaemia. Bone Marrow Transplantation, 2020;55(9):1854-1856.
9. Limin Liu, Xiuli Wang, Song Jin, Lin Hao, Yanming Zhang, Xingxia Zhang, Depei Wu*. Haploidentical hematopoietic stem cell transplantation for nonresponders to immunosuppressive therapy against acquired severe aplastic anemia. Bone Marrow Transplant,2016;51(3):424-427.
10. Limin Liu, Shan Liu, Yanming Zhang, Huifen Zhou, Qingyuan Wang, Hong Tian, et al. Excellent Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Paroxysmal Nocturnal Hemoglobinuria: A Single-Center Study. Biology of Blood and Marrow Transplantation, 2019; 1544-1549.
11. Limin Liu, Yanming Zhang, Shan Liu, Huifen Zhou, Qingyuan Wang, Hong Tian, et al. Outcomes of haploidentical haematopoietic stem cell transplantation for paroxysmal nocturnal haemoglobinuria. Bone Marrow Transplantation, 2020 ;55(8):1635-1637.
12. Limin Liu, Xingxia Zhang, Huiying Qiu, Xiaowen Tang, Yue Han, Chengcheng Fu, et al. HLA-mismatched stem cell microtransplantation compared to matched-sibling donor transplantation for intermediate/high-risk acute myeloid leukemia. Annals of Hematology, 2019;98(5):1249-1257.
13. Meiqing Lei, Limin Liu, Depei Wu. Priming with GM-CSF instead of G-CSF enhances CAG induced apoptosis of acute monocytic leukemia cells in vitro. Cancer Chemotherapy and Pharmacology, 2019; 84:265–273. (并列第一作者)
14. Meiqing Lei, Limin Liu, Zhiming Wang, Depei Wu. Efficacy of high?dose cytarabine and aclarubicin in combination with G?CSF regimen compared to intermediate/high?dose cytarabine and standard?dose cytarabine induction regimen for non?remission acute myeloid leukemia. Indian J Cancer, 2019;56:167-172. (并列第一作者)
15. Hong Tan, Li Gan, Xiaoming Fan, Limin Liu, Shan Liu. Diagnostic value of circular RNAs as effective biomarkers for cancer: a systematic review and meta-analysis. OncoTargets and Therapy, 2019:12 2623–2633(并列通讯作者)
16. Qi Qu, Limin Liu#,Guanghua Chen,Yang Xu, Xiaojin Wu, Depei Wu. Endothelial progenitor cells promote efficient ex vivo expansion of cord blood–derived hematopoietic stem/progenitor cells. Cytotherapy, 2016; 18: 452–464(并列第一作者)
17. Limin Liu, Wenjing Jiao, Yanming Zhang, Qi Qu, Xiaoli Li, Depei Wu. Efficacy of low-dose cytarabine and aclarubicin in combination withgranulocyte colony-stimulating factor (CAG regimen) compared to Hyper-CVAD regimen as salvage chemotherapy in relapsed/refractory Philadelphia chromosome-negative acute lymphoblastic leukemia. Leukemia Research, 2015; 39: 323–328.
18. Limin Liu, Li Ding, Lin Hao, Xingxia Zhang, Xiaoli Li, Liansheng Zhang, Zhengdong Hao, Meiqing Lei, Yanming Zhang, Depei Wu. The efficacy of porcine anti-human lymphocyte immunoglobulin with cyclosporine A in comparison to rabbit antithymocyte immunoglobulin as a first-line treatment in patients with acquired severe aplastic anemia. Annals of Hematology, 2015; 94: 729–737.
19. Limin Liu, Qi Qu, Wenjing Jiao, Yanming Zhang, Xiaoli Li, Chao Ding, Depei Wu. Increasing aclarubicin dose in a low-dose cytarabine, aclarubicin and granulocyte colony-stimulating factor chemotherapeutic combination is efficacious for relapsed/refractory mixed-phenotype acute leukemia. Leukemia Research, 2015; 39: 805–811.
20. Guoqiang Lin, Limin Liu#, Guangsheng Zhao, Yejun Si, Xingxia Zhang, Yumei Sun, Shuhua Lu, Yanming Zhang. Myeloid antigen-positive T cell acute lymphocytic leukemia with t (14;18) and trisomy 10: report of one case and literature review. Archives of Iranian Medicine, 2015;18:537-541. (并列第一作者)
21. Qi Qu, Limin Liu#, Yanming Zhang, Xiaoli Li, Depei Wu. Modified CAG regimen improves the therapeutic efficacy for relapsed/refractory acute myeloid leukemia than CAG regimen. Leukemia Research, 2015; 39: 1353–1359. (并列第一作者)
22. Xiaoli Li, Limin Liu#, Yanming Zhang, Qi Qu, Yao Yao, Tong Wang, Wenjing Jiao, Depei Wu. Modified CAG regimen compared with FLAG regimen for relapsed/refractory acute lymphoblastic leukemia. Leukemia Research, 2015; 39: 1201–1206. (并列第一作者)
23. Limin Liu, Yanming Zhang, Zhengming Jin, Xingxia Zhang, Guangsheng Zhao, Yejun Si, Guoqiang Lin, Aidi Ma, Yingxin Sun, Li Wang, Depei Wu. Increasing the dose of aclarubicin in low-dose cytarabine and aclarubicin in combination with granulocyte colonystimulating factor (CAG regimen) can safely and effectively treat relapsed or refractory acute myeloid leukemia. Int J Hematol, 2014; 99:603–608.
24. Liu Limin, Sun Yumei, Si Yejun, Lin Guoqiang, Zhang Xingxia, Zhao Guangsheng, Zhang Yanming, Wu Depei. Vindesine induces rhabdomyolysis in patients with acute lymphoblastic leukemia. Chinese Medical Journal, 2014;127:3835–3836.
25. Limin Liu, Xin Zhao, Miao Miao, Yanming Zhang, Wenjing Jiao, Meiqing Lei, Huifen Zhou, Qingyuan Wang, Yifeng Cai, Liyun Zhao, Xiaohui Shangguan, Zefa Liu, Jinge Xu, Fengkui Zhang, Depei Wu. Inefficacy of immunosuppressive therapy for severe aplastic anemia (SAA) progressing from non-SAA: improved outcome after allogeneic haematopoietic stem cell transplantation. Frontiers in Oncology, 2021;11:739561.
26. Meiqing Lei , Xiaoli Li , Yanming Zhang, Qi Qu, Wenjing Jiao, Huifen Zhou, Qingyuan Wang, Huiying Qiu, Xiaowen Tang, Yue Han, Chengcheng Fu, Zhengming Jin, Suning Chen, Aining Sun, Miao Miao, Limin Liu, Depei Wu. Comparable Outcomes and Health Related Quality of Life for Severe Aplastic Anemia: Haploidentical Combined With a Single Cord Blood Unit vs Matched Related Transplants. Frontiers in Oncology, 2022, 18;11:714033.（并列通讯作者）
27. Limin Liu , Bing Han, Yanming Zhang, Meiqing Lei, Rongrong Liu, Zenghua Lin, Wenjing Jiao, Fengkui Zhang, Rong Fu, Xin Zhao, Miao Miao, Liansheng Zhang, Depei Wu. First-line treatment of severe aplastic anemia: immunosuppressive therapy plus eltrombopag versus haploidentical hematopoietic stem cell transplantation, a multicenter prospective study. Bone Marrow Transplantation,2024, doi: 10.1038/s41409-024-02377-1.?Online ahead of print.
28. Xiaoli Li，Xiaohui Shangguan，Hong Wang， Qingyuan Wang，Yanming Zhang，Bing Han，Rongrong Liu，Fengkui Zhang，Rong Fu， Zenghua Lin，Miao Miao， Xiao Ma， Meiqing Lei，Depei Wu，Limin Liu. Comparison of efficacy of eltrombopag combined with immunosuppression in the treatment of severe aplastic anemia and very severe aplastic anemia: real-world data and evidence. Annals of Hematology, 2024,103(9):3483-3491.

发表中文文章：
1. 刘立民，张连生?.黄芪多糖体外对慢性粒细胞白血病患者治疗前后浆细胞样树突状细胞功能及成熟的影响.中华血液学杂志,第31卷，第11期，740-743，2010
2. 刘立民，张兴霞，张彦明?，赵广圣，孙雨梅，吴德沛.急性髓系白血病患者外周血Th22细胞水平的变化.中华血液学杂志,第33卷，第2期，133-135，2012
3. 刘立民，张兴霞，赵广圣，司叶俊，林国强，张彦明?，何广胜，吴德沛.异基因造血干细胞移植后慢性移植物抗宿主病患者外周血中Th22型细胞及相关细胞因子的测定. 中华器官移植杂志，第33卷，第8期，504-505，2012
4. 刘立民，张兴霞，赵广圣，司叶俊，林国强，张彦明?，何广胜，吴德沛.急性淋巴细胞白血病患者外周血Th22细胞水平的变化及意义.中华血液学杂志，第33卷，第12期，985-988，2012
5. 刘立民，张兴霞，赵广圣，司叶俊，林国强，张彦明?，何广胜，吴德沛.再生障碍性贫血患者外周血Th22细胞水平的变化及意义，中华医学杂志，第93卷，第20期，1537-1540，2013
6. 刘立民，张彦明，陆沭华，孙雨梅，何广胜.黄芪多糖对浆细胞样树突状细胞功能及成熟的影响. 中国免疫学杂志, 第26卷，第8期，712-715，2010
7. 刘立民，张彦明，陆沭华，赵广圣，张兴霞，崔红霞.黄芪多糖促进急性髓细胞白血病患者浆细胞样树突状细胞成熟.中国肿瘤生物治疗杂志, 第17卷，第6期，657-660，2010
8. 韩雪花，刘立民?，张彦明，张兴霞，赵广圣，司叶俊，林国强，何广胜，吴德沛.骨髓增生异常综合征患者外周血Th22细胞水平的变化及意义. 中国免疫学杂志，第29卷，第1期，62-65，2013(通讯作者)
9. 刘立民，张兴霞，赵广圣，司叶俊，林国强，张彦明?，何广胜，吴德沛.原发免疫性血小板减少症患者外周血Th22细胞水平的变化及意义.细胞与分子免疫学杂志，第28卷，第12期，1314-1316，2012
10. 刘立民，韩雪花，张兴霞，赵广圣，司叶俊，林国强，张彦明?，何广胜，吴德沛.雷公藤内酯醇对原发免疫性血小板减少症患者浆细胞样树突状细胞功能及成熟的影响.中华血液学杂志，第33卷，第9期，720-724，2012
11. 刘立民?，焦雯静，张兴霞，张彦明，赵广圣，崔红霞，孙雨梅，陆沭华.雷公藤内酯醇对浆细胞样树突状细胞功能及成熟的影响.中华微生物学和免疫学杂志，第31卷，第1期，6-9，2011
12. 刘立民?，焦雯静，张兴霞，张彦明，赵广圣，孙雨梅，陆沭华. 雷公藤内酯醇对系统性红斑狼疮患者DC细胞功能及成熟的影响.中华微生物学和免疫学杂志，第31卷，第9期，824-829，2011
13. 张兴霞，刘立民?，张彦明. 急性白血病异基因造血干细胞移植后髓外复发二例.白血病·淋巴瘤，第21卷，第6期，369-371，2012(通讯作者)
14. 刘立民，吴德沛?. 调节性B细胞与免疫相关性疾病的关系. 中华微生物学和免疫学杂志， 第33卷，第11期，877-881，2013
15. 刘立民，吴德沛?. 造血干细胞移植长期生存患者生存质量评估. 中国实用内科杂志，第34卷，第2期，95-98，2014
16. 郝琳，刘立民, 张彦明. 以神经系统损害为首发表现的血液病24例临床分析. 江苏医药, 2014;40(18):2224-2225. (通讯作者)
17. 杨广辉, 刘立民, 韩正祥. TACE联合PMCT对原发性肝癌患者Th22细胞数量和功能的影响. 中华消化病与影像杂志（电子版）. (通讯作者)
18. 赵丽云, 刘立民, 苗瞄, 仇惠英, 唐晓文, 韩悦, 傅琤琤, 金正明, 孙爱宁, 吴德沛.无关供者脐血移植治疗重型再生障碍性贫血18例疗效观察. 中华器官移植杂志,第39卷,第2期,116-117,2018(并列第一作者)
19. 刘立民, 张彦明, 周惠芬, 汪清源, 苗瞄, 仇惠英, 唐晓文, 韩悦, 傅琤琤, 金正明, 孙爱宁, 吴德沛. 单倍体联合第三方脐血移植治疗重型再生障碍性贫血127例疗效观察. 中华血液学杂志, 2018;39(8):624-628.
20. 刘立民，周惠芬，汪清源，仇惠英，唐晓文，韩悦，傅琤琤，金正明，陈苏宁，孙爱宁，苗瞄，吴德沛.单倍型与同胞全相合造血干细胞移植治疗阵发性睡眠性血红蛋白尿症疗效比较. 中华血液学杂志, 2019;40(4):306-311.
21. 刘立民，周惠，汪清源，仇惠英，唐晓文，韩悦，傅琤琤，金正明，陈苏宁，
孙爱宁，苗瞄，吴德沛. 异基因造血干细胞移植治疗阵发性睡眠性血红蛋白尿症（PNH）与PNH-再生障碍性贫血综合征疗效比较. 中华血液学杂志2019;40(6):472-476.

主持或参加科研项目（课题）及人才计划项目情况

1. 江苏省自然科学基金（BK20180202）：HIF1α-SDF1-Notch1信号轴在调控外源内皮祖细胞参与造血干细胞移植血管龛重建中的作用研究，2018-2021
2. 苏州市重点研发项目（SKY2021040）：单倍体联合脐血双重移植模式治疗重型再生障碍性贫血机制探究，2021-2024

获得学术奖励

1. Th22细胞在白血病及造血干细胞移植物抗宿主病患者的临床价值，获2016年江苏省卫生厅新技术引进二等奖
2. 替代供者造血干细胞移植治疗重型再生障碍性贫血临床应用，获2021年江苏省卫生健康新技术引进二等奖
3. 免疫治疗新技术在恶性血液病中的临床转化及推广应用，获2022年中华医学科技奖二等奖
4. 免疫治疗新技术在恶性血液病中的临床转化及推广应用，获2022年江苏省科学技术奖一等奖