董宁征 研究员  博士生导师

研究员，江苏省333 高层次培养人才。1992年毕业于苏州医学院，获医学学士学位。2002年获苏州大学医学博士。2001-2002年在美国加州 Berlex Biosciences 心血管中心访问学习。
主要从事血管生物学、血栓与止血的基础与临床研究工作。研究发现蛋白酶Corin具有调控血压及心功能的作用，还发现Corin在妊娠子宫表达的重要作用及调控机制，近期还发现Corin参与调控糖脂代谢，重组Corin蛋白可改善心衰小鼠的心功能。相关工作已在Nature, Nature Medicine, PNAS, PLoS Biol, Biomaterials, eLife, Circ Heart Fail, J Biol Chem，JAHA 等杂志发表。

主要研究方向:
1.血管生物学
2.血栓与止血

科研项目：
1.国家自然基金面上项目（项目负责人）：蛋白酶corin通过Wnt信号通路调控心脏结构和功能的机制研究/ 32471158；起止年月：2025.01-2028.12；经费：50 万元
2.国家自然基金面上项目（项目负责人）：心脏蛋白酶corin在糖脂代谢中的作用及机制研究/ 32171112；起止年月：2022.01-2025.12；经费:58万元
3.国家自然基金面上项目（项目负责人）：KLF17在子宫Corin表达调控及子痫前期中的作用研究/ 81873840；起止年月：2019.01-2022.12；经费：56 万元
4.国家自然基金面上项目（项目负责人）：可溶性corin对心力衰竭的治疗作用及机制研究/ 81570457；起止年月：2016.01-2019.12；经费：57 万元
5.国家自然基金面上项目（项目负责人）：妊娠期子宫Corin表达调控机制及其在子痫前期发病中的作用/ 81370718；起止年月：2014.01-2017.12；经费：70 万元
6. 国家重大科学研究计划 (973)：母-胎交互对话异常致妊娠相关重大疾病的分子机制/2015CB943300；起止年月：2015.01 – 2019.08；经费：93 万元

7.教育部重大科技项目（项目负责人）：心脏酶Corin在高血压性疾病中的机理和应用研究/213016A；起止年月：2014年1月- 2016年12月；经费：50 万元

代表性论文（*通讯作者）：
1.Zhang Y, Sun S, Du C, Hu K, Zhang C, Liu M, Wu Q*, Dong N*. Transmembrane serine protease TMPRSS2 implicated in SARS-CoV-2 infection is autoactivated intracellularly and requires N-glycosylation for regulation. J Biol Chem. 2022 Oct 26:298:102643. 
2.Niu Y, Zhang S, Gu X, Zhou T, Li F, Liu M, Wu Q* and Dong N*. Recombinant soluble corin improves cardiac function in mouse models of heart failure. J Am Heart Assoc. 2021;10:e019961.
3.He M, Zhou T, Niu Y, Feng W, Gu X, Xu W, Zhang S, Wang Z, Zhang Y, Wang C, Dong L, Liu M, Dong N* and Wu Q*. The protease corin regulates electrolyte homeostasis in eccrine sweat glands. PLoS Biol. 2021;19:e3001090.
4.Zhang C, Chen Y, Sun S, Zhang Y, Wang L, Luo Z, Liu M, Dong L, Dong N*, Wu Q*. Zhang S, Wang Z.  A conserved LDL receptor motif regulates corin and CD320 membrane targeting in polarized renal epithelial cells. eLife. 2020;9:e56059.
5.Wang C, Wang Z, He M, Zhou T, Niu Y, Sun S, Li H, Zhang C, Zhang S, Liu M, Xu Y, Dong N*, Wu Q*. Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19425-34.
6.Sun S, Wang L, Zhang S, Zhang C, Chen Y, Wu Q*, Dong N*. N-glycan in the scavenger receptor cysteine-rich domain of hepsin promotes intracellular trafficking and cell surface expression. Int J Biol Macromol. 2020 Jun 15;161:818-27. 
7.Hu Y, Yan R, Zhang C, Zhou Z, Liu M, Wang C, Zhang H, Dong L, Zhou T, Wu Y, Dong N*, Wu Q*. High-mobility group box 1 from hypoxic trophoblasts promotes endothelial microparticle production and thrombophilia in preeclampsia. Arterioscler Thromb Vasc Biol. 2018;38:1381-91. 
8.Chen S, Cao P, Dong N, Peng J, Zhang C, Wang H, Zhou T, Yang J, Zhang Y, Martelli EE, Naga Prasad SV, Miller RE, Malfait AM, Zhou Y, Wu Q. PCSK6-mediated corin activation is essential for normal blood pressure. Nature Med. 2015;21:1048-53.
9.Sun S, Liu Z, Zhou H, Li G, Liu M, Yao J, Zhou T, An G, Wu Q*, Dong N*. The role of fucosylation in the promotion of endothelial progenitor cells in neovascularization and bone repair. Biomaterials. 2014;35:3777-85.
10.Cui Y#, Wang W#, Dong N#, Lou J#, Srinivasan DK, Cheng W, Huang X, Liu M, Fang C, Peng J, Chen S, Wu S, Liu Z, Dong L, Zhou Y, Wu Q. Role of corin in trophoblast invasion and uterine spiral artery remodeling in pregnancy. Nature. 2012;484:246-50. (Selected by Faculty1000), # Co-first Authors. 

其他论文（*通讯作者）：
1.Gu X, Liu M, Wang M, Wang K, Zhou T, Wu Q*and Dong N*. Corin deficiency alleviates mucosal lesions in a mouse model of colitis induced by dextran sulfate sodium. Life Sci. 2024 Feb 15;339:122446.
2.Niu Y, Zhou T, Zhang S, Li W, Wang K, Dong N*, Wu Q*. Corin deficiency impairs cardiac function in mouse models of heart failure. Front Cardiovasc Med. 2023 Aug 11;10:1164524. 
3.Sun S, Hu K, Wang L, Liu M, Zhang Y, Dong N*, Wu Q*. Spatial position is a key determinant of N-glycan functionality of the scavenger receptor cysteine-rich domain of human hepsin. FEBS J. 2023 Aug;290(16):3966-82.
4.Gu X, Wang K, Li W, He M, Zhou T, Liu M, Wu Q, Dong N. Corin Deficiency Diminishes Intestinal Sodium Excretion in Mice. Biology (Basel). 2023 Jul 1;12(7):945.
5.Zhou T, Zhang S, Du C, Wang K, Gu X, Sun S, Zhang X, Niu Y, Wang C, Liu M, Dong N*, Wu Q*. Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis. Int J Mol Sci. 2022 Sep 24;23(19):11251.
6.Zhang X, Li W, Zhou T, Liu M, Wu Q*, Dong N*. Corin Deficiency Alters Adipose Tissue Phenotype and Impairs Thermogenesis in Mice. Biology (Basel). 2022 Jul 23;11(8):1101.
7.Zhang W, Li S, Lou J, Li H, Liu M, Dong N, Wu Q. Atrial natriuretic peptide promotes uterine decidualization and a TRAIL-dependent mechanism in spiral artery remodeling. J Clin Invest. 2021 Oct 15;131(20):e151053.
8.Dong N, Niu Y, Chen Y, Sun S, Wu Q. Function and regulation of corin in physiology and disease. Biochem Soc Trans. 2020:48 1905–16.
9.Zhang C, Zhang Y, Zhang S, Wang Z, Sun S, Liu M, Chen Y, Dong N*, Wu Q*. Intracellular autoactivation of TMPRSS11A, an airway epithelial transmembrane serine protease. J Biol Chem. 2020: 295(36):12686-96.
10.He M, Zhang Y, Li H, Liu M, Dong N*, Wu Q*. A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus. Biochem Biophys Res Commun. 2020 Sep 10;530(1):35-41.
11.Wang L, Zhang C, Sun S, Chen Y, Hu Y, Wang H, Liu M1, Dong N*, Wu Q*. Autoactivation and calpain-1-mediated shedding of hepsin in human hepatoma cells. Biochem J. 2019 Aug 28;476(16):2355-2369.
12.Yan R, Liu M, Hu Y, Wang L, Wang C, Jiang Y, Zhou Q, Qi X, Dong N*, Wu Q*. Ectopic expression of human airway trypsin-like protease 4 in acute myeloid leukemia promotes cancer cell invasion and tumor growth. Cancer Med. 2019 2019;8:2348–59.
13.Hu Y, Li H, Yan R, Wang C, Wang Y, Zhang C, Liu M, Zhou T, Zhu W, Zhang H, Dong N*, Wu Q*: Increased neutrophil activation and plasma DNA levels in patients with preeclampsia. Thromb Haemost. 2018;118:2064-73.
14.Zhou H, Zhu J, Liu M, Wu Q*, Dong N*. Role of the protease corin in chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells. J Tissue Eng Regen Med. 2018;12(4) 973-82. 
15.Zhang Y, Zhou T, Niu Y, He M, Wang C, Liu M, Yang J, Zhang Y, Zhou J, Fukuda K, Qin J, Dong N*, Wu Q*. Identification and functional analysis of CORIN variants in hypertensive patients. Hum Mutat. 2017 Dec;38(12):1700-10.
16.Zhang Z, Hu Y, Yan R, Dong L, Jiang Y, Zhou Z, Liu M, Zhou T, Dong N*, Wu Q*.  The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss. Sci Rep. 2017 Mar 24;7:45262. 
17.Wang Z, Dong N, Niu Y, Zhang Z, Zhang C, Liu M, Zhou T, Wu Q, Cheng K. Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction.  J Cell Mol Med. 2017 Oct;21(10):2432-40. 
18.Dong L, Wang H, Dong N, Zhang C, Xue B, Wu Q. Localization of corin and atrial natriuretic peptide expression in human renal segments. Clin Sci (Lond). 2016 Sep 1;130(18):1655-64
19.Zhang Y, Li H, Zhou J, Wang A, Yang J, Wang C, Liu M, Zhou T, Zhu L, Zhang Y, Dong N*, Wu Q*. A corin variant identified in hypertensive patients that alters cytoplasmic tail and reduces cell surface expression and activity. Sci Rep 2014;4:7378.
20.Dong N, Zhou T, Zhang Y, Liu M, Li H, Huang X, Liu Z, Wu Y, Fukuda K, Qin J, Wu Q. Corin mutations K317E and S472G from preeclamptic patients alert zymogen activation and cell surface targeting. J Biol Chem. 2014;289:17909-16.
21.Dong N, Fang C, Jiang Y, Zhou T, Liu M, Zhou J, Shen J, Fukuda K, Qin J, Wu Q. Corin mutation R539C from hypertensive patients impairs zymogen activation and generates inactive alternative ectodomain fragment. J Biol Chem. 2013;288:7867-74.
22.Dong N, Wu Q: Corin. In: Handbook of Proteolytic Enzymes. 3rd Edition, (Rawlings ND, Salvesen GS, Eds), pp. 3007-3010, Academic Press, London, 2013.（论著）
23.Zhou H, Liu W, Zhu J, Liu M, Fang C, Wu Q, Dong N*. Reduced serum corin levels in patients with osteoporosis. Clin Chim Acta. 2013;426:152-6. 
24.Gao L, Liu M, Dong N, Jiang Y, Lin C-Y, Huang M, Wu D, Wu Q. Matriptase is highly up-regulated in chronic lymphocytic leukemia and promotes cancer cell invasion. Leukemia. 2013;27:1191-4.
25.Fang C, Shen L, Dong L, Liu M, Shi S, Dong N*, Wu Q*. Reduced urinary corin levels in patients with chronic kidney disease. Clin Sci (Lond). 2013;124:709-17. 
26.Lu Q*, Dong N*, Wang Q, Yi W, Wang Y, Zhang S, Gu H, Zhao X, Tang X, Jin B, Wu Q, Brass LF, Zhu L. Increased levels of plasma soluble Sema4D in patients with heart failure. PloS One 2013;8:e64265. *Co-first Authors.
27.Dong N*, Chen S, Wang W, Zhou Y, Wu Q. Corin in clinical laboratory diagnostics. Clin Chim Acta. 2012;413:378-83.
28.Dong J, Zhao X, Shi S, Ma Z, Liu M, Wu Q, Ruan C, Dong N*. Identification and functional analysis of a novel von Willebrand factor mutation in a family with type 2A von Willebrand disease. PloS One. 2012;7:e33263.
29.Dong N, Chen S, Yang J, He L, Liu P, Zheng D, Li L, Zhou Y, Ruan C, Plow E, Wu Q. Plasma soluble corin in patients with heart failure. Circ Heart Fail. 2010;3:207-11.
30.Dong N, Dong J, Liu P, Xu L, Shi S, Wu Q: Effects of anticoagulants on human plasma soluble corin levels measured by ELISA. Clin Chim Acta. 2010;411:1998-2003.