姓名:陈苏宁
擅长疾病：血液肿瘤
个人简介：
1973年生于江苏省南通市，2003年7月获苏州大学血液病博士学位，学位论文荣获2005年全国优秀博士学位论文提名。2003年8月起于苏州大学附属第一医院血液科从事血液病临床诊疗工作。2007年4月，获得国际著名的德国洪堡基金会资助，作为洪堡学者于德国DSMZ从事白血病合作研究。担任苏州大学附属第一医院教授、主任医师、博士生导师，血液科副主任、血液研究室主任，江苏省杰出青年基金获得者、江苏省333工程重点人才（第2层次）、江苏省医学重点人才、姑苏卫生重点人才、江苏省六大高峰重点人才。
科研情况：
在国内首次获得美国白血病淋巴瘤协会科研项目资助，主持863子项目、973子课题、精准医学重大专项子课题、国家自然科学基金面上项目、江苏省杰出青年基金等科研项目共9项，以通讯作者或第一作者在Blood、Leukemia、Cell Reports、Haematologica等国际权威期刊发表论文48篇（通讯作者39篇）。获国家科技进步奖二等奖（2016，排名第3）1项、江苏省科技进步奖一等奖（2009和2015，排名第3）2项、教育部科技进步奖一等奖（2015，排名第3）1项、中华医学科技奖二等奖（2015，排名第2）1项，获2017年第十届吴孟超医学青年基金奖。
学术任职：
担任第九和第十届中华医学会血液学分会青年委员会副主任委员、第九和第十届中华医学会血液学分会实验诊断学组副组长、中国病理生理学会实验血液学分会委员、江苏省医学会血液学分会副主任委员，担任《中华血液学杂志》编委。
一、教育背景：
(1) 2000.9–2003.6, 苏州大学, 医学部第一临床学院， 研究生，医学博士
(2) 1997.9–2000.6, 东南大学, 医学院, 研究生，医学硕士
(3) 1992.9–1997.6, 南京铁道医学院, 临床医学系, 本科，医学学士
二、科研与学术工作经历：
(1) 2014.10-至今, 苏州大学附属第一医院, 血液科, 教授、主任医师
(2) 2012.10-2014.9, 苏州大学附属第一医院, 血液科, 教授、副主任医师
(3) 2009.10-2012.9, 苏州大学附属第一医院, 血液科, 副主任医师、副教授
(4) 2005.10-2009.9, 苏州大学附属第一医院, 血液科, 主治医师
(5) 2003.8-2005.9, 苏州大学附属第一医院, 血液科, 住院医师
三、研究领域
血液肿瘤的分子机制与靶向治疗
四、取得研究成果和获得学术奖励情况
1、期刊论文（近5年内发表的5篇代表性论著）
(1) Tianhui Liu(#) ; Lijun Wen(#) ; Hongjian Yuan (#); Yi Wang (#) ; Li Yao; Yang Xu; Jiannong Cen; Changgeng Ruan; Depei Wu; Suning Chen(*) ,Identification ofnovel recurrent CPSF6-RARG fusions in acute myeloid leukemia resembling acute promyelocytic leukemia, Blood, 2018.2.27, online(online)
(2) Li Yao(#) ; Lijun Wen(#) ; Nana Wang; Tianhui Liu; Yang Xu; Changgeng Ruan;Depei Wu; Suning Chen ,(*)Identification of novel recurrent STAT3-RARA fusions in acute promyelocytic leukemia lacking t(15;17)(q22;q12)/PML-RARA, Blood, 2017.12.13, 31(8): 935~939
(3) Tongtong Zhang(#) ; Yang Xu(#) ; Jinlan Pan; Hongzhi Li; Qinrong Wang;Lijun Wen; Depei Wu1; Aining Sun(*) ; Suning Chen(*)；High frequency of RUNX1 mutation in myelodysplastic syndrome patients with whole-arm translocation of der(1;7)(q10;p10), Leukemia, 2017.10.31, 31(10): 2257~2260
(4) Ping N(#) ; Sun A(#) ; Song Y (#) ; Wang Q (#); Yin J; Cheng W; Xu Y; Wen L; Yao H; Ma L; Qiu H; Ruan C; Wu D(*) ; Chen S(*)；Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemia, Leukemia, 2016.7.6, 31(1): 195~202
(5) Ping, Nana(#) ; Qiu, Huiying(#) ; Wang, Qian (#); Dai, Haiping; Ruan,Changgeng; Ehrentraut, Stefan; Drexler, Hans G.; MacLeod, Roderick A. F.; Chen Suning(*) , Establishment and genetic characterization of a novel mixed-phenotype acute leukemia cell line with EP300-ZNF384 fusion;JOURNAL OFHEMATOLOGY & ONCOLOGY, 2015.8.21, 8
2、期刊论文（近5年内发表的其他论著）
(1) Zong, Xiangping(#) ; Yao, Hong; Wen, Lijun; Ma, Liang; Wang, Qinrong;Yang, Zhiluo; Zhang, Tongtong; Chen, Suning(*) ; Wu Depei(*),ASXL1 mutations are frequent in de novo AML with trisomy 8 and confer an unfavorable prognosis; Leukemia and Lymphoma, 2017, 58(1): 204~206
(2) Yao, Li (#); Cen, Jiannong; Pan, Jinlan; Liu, Dandan; Wang, Yong; Chen,Zixing; Ruan, Changgeng(*);Chen, Suning(*),TAF15-ZNF384 fusion gene in childhood mixed phenotype acute leukemia , CANCER GENETICS, 2017.2, 211: 1~4
(3) Yu, Yan (#) ; Zhang, Tongtong(#) ; Wang, Qinrong; Wu, Depei; Pan, Jinlan;Liang, Jianying; Chen, Suning (*); Sun, Aining (*),Counting bone marrow blasts as a percentage of nonerythroid cells improves the prognostic evaluation of MDS with erythroid predominance ;AMERICAN JOURNAL OF HEMATOLOGY, 2017.4, 92(4):E55~E57
(4) Cai, W-Z(#) ; Cen, J-N; Chen, J.; Chen, F.; Fu, C-C; Han, Y.; Jin, Z-M;Ma, X.; Miao, M.; Qiu, H-Y; Tang, X-W; Xue, S-L; Sun, A-N; Chen, S-N(*) ; Wu,D-P (*),Major molecular response prior to allogeneic hematopoietic stem cell transplantation predicts better outcome in adult Philadelphia-positive acute lymphoblastic leukemia in first remission;BONE MARROW TRANSPLANTATION, 2017.3, 52(3): 470~472
(5) Suning Chen(#) ; Stefan Nagel; Bjoern Schneider; Haiping Dai; Robert Geffers; Maren Kaufmann; Corinna Meyer; Claudia Pommerenke; Kenneth S. Thress;Jiao Li; Hilmar Quentmeier; Hans G. Drexler (*) ; Roderick A. F. MacLeod ,(*) A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target – a short report, International Society for Cellular Oncology, 2017.10.06, 41:93~101
(6) Liangjing Xu(#); Jinge Xu(#) ; Shoubao Ma (#) ; Xiaoli Li; Mingqing Zhu;Suning Chen; Yue Han; Xiaowen Tang; Zhengzheng Fu; Huiying Qiu; Jianhua Yu(*) ; Depei Wu(*) ; Xiaojin Wu (*) ,High Tim-3 expression on AML blasts could enhance chemotherapy sensitivity, Oncotarget, 2017.6.14, 8(60): 102088~102096
(7) Guangying Sheng(#) ; Jian Zhang(#); Zhao Zeng ; Jinlan Pan; Qinrong Wang;Lijun Wen; Yang Xu; Depei Wu(*) ; Suning Chen(*)；Identification of a novel CSF3R-SPTAN1 fusion gene in an atypical chronic myeloid leukemia patient with t(1;9)(p34;q34) by RNA-Seq, Cancer Genetics, 2017.5.19, (216-217): 16~19
(8) Shuangfeng Zhang (#); Liang Ma(#) ; Yafeng Chen; Huan Xu; Suning Chen(*)；WenzhongWu(*)；Overexpression of HHEX in Acute Myeloid Leukemia with t(8;21)(q22;q22) Translocation, Annals of Clinical & Laboratory Science, 2017,47(6): 687~697
(9) Guangying Sheng(#) ; Zhao Zeng (#); Jinlan Pan; Linbing Kou; Qinrong Wang;Hong Yao; Lijun Wen; Liang Ma; Depei Wu; Huiying Qiu; Suning Chen(*),Multiple MYO18A-PDGFRB fusion transcripts in a myeloproliferative neoplasm patient with t(5;17)(q32;q11), Molecular Cytogenetics, 2017.2.27, 10
(10) Han, Qiaoyan ; He, Xuefeng; Wu, Lili; Gao, Feng; Ye, Jinsong; Wu,(#)Lingyu; Chen, Lu; Jiang, Xin; Sun, Miao (*); Chen, Suning(*),Downregulated stromal antigen 2 expression in de novo acute myeloid leukemia patients; Experimental and Therapeutic Medicine, 2017.2, 13(2): 530~534
(11) Jun Liu(#) ; Bo Guo; Zhuo Chen; Nayi Wang; Michelina Iacovino; Jijun Cheng; Christine Roden; Wen Pan; Sajid Khan; Suning Chen; Michael Kyba; Rong Fan; Shangqin Guo; Jun Lu(*) , miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism, Blood, 2017, 129(11): 1491~1502
(12) Guangying Sheng(#) ; Chaohui Dong; Ri Zhang; Miao Miao; Wu Depei; Suning Chen；Seng Chuen Tan; Chao Liu; Tengbin Xiong(*) ,Societal implications of medical insurance coverage for imatinib as first-line treatment of chronic myeloid leukemia in China: a cost effectiveness analysis, Journal of Medical Economics, 2017.4, 20(4): 371~381
(13) Maoxiang Qian(#) ; Hui Zhang(#) ; Shirley Kow-Yin Kham; Shuguang Liu;Chuang Jiang; Xujie Zhao; Yi Lu; Charnise Goodings; Ting-Nien Lin; Ranran Zhang; Takaya Moriyama; Zhaohong Yin; Zhenhua Li; Thuan Chong Quah; Hany Ariffin; Ah Moy Tan; Shuhong Shen; Deepa Bhojwani; Shaoyan Hu; Suning Chen;Huyong Zheng; Ching-Hon Pui; Allen Eng-Juh Yeoh (*); Jun J Yang(*) , Whole Transcriptome Sequencing Identified a Distinct Subtype of Acute Lymphoblastic Leukemia with Predominant Genomic Abnormalities of EP300 and CREBBP, Genome Research, 2017.2, 27(2): 185~195
(14) Chen, Meiyu(#) ; Xiong, Fei; Ma, Liang; Yao, Hong; Wang, Qinrong; Wen,Lijun; Wang, Qian; Gu, Ning; Chen, Suning (*),Inhibitory effect of magnetic Fe3O4 nanoparticles coloaded with homoharringtonine on human leukemia cells in vivo and in vitro; INTERNATIONAL JOURNAL OF NANOMEDICINE, 2016, 11: 4413~4422
(15) Guangying Sheng (#); Zhao Zeng(#) ; Jinlan Pan; Qinrong Wang; Hong Yao;Lijun Wen; Liang Ma; Depei Wu; Suning Chen (*)；t(1;9)(p34;q34)/SFPQ-ABL1 Fusion in a Patient with Ph-Like Common B-Cell Acute Lymphoblastic Leukemia, Acta Haematol, 2016.10.2, 137: 40~43
(16) Tongtong Zhang(#) ; Yang Xu (#); Jinlan Pan; Huiying Qiu; Depei Wu;Suning Chen(*); Aining Sun (*),Monosomal karyotype of chromosome 5/7 was an independent poor prognostic factor for Chinese myelodysplastic syndrome patients, Cancer Genetics, 2016.9, 209(9): 423~429
(17) Jiao Li(#) ; Lijun Wen; Junming Tang; Heng Zhang; Zhigang Zhou; Yunping Zhang; Yafeng Chen; Sisi Chen; Qiuxia Wang; Jianwei Shao; Wenzhong Wu; SuningChen (*),Prevalence of Monoclonal Gammopathy of Undetermined Significance in an Apparently Healthy Yixing Population in Mainland China, Acta Haematol, 2016.9.19, 137: 17~19
(18) Nana Wang(#) ; Xiaojin Wu(#) ; Guangying Sheng; Liang Ma; Lijun Wen; Hong Yao; Suning Chen (*)；MLL-SEPT5 Fusion Transcript in Two de novo Acute Myeloid Leukemia Patients With t(11;22)(q23;q11), General Laboratory Medicine, 2016.5.16, 36: 501~503
(19) Mengyun Li (#); Lijun Wen; Jiannong Cen; Yufeng Feng; Suning Chen(*)；JAK2V617F allele burden in patients with myeloproliferative neoplasms carrying Trisomy 9, and its relationship with clinical phenotypes, Int J Hematol, 2016.3.7, 103: 599~601
(20) Xu, Yang(#) ; Sun, Yanjun(#) ; Shen, Hongjie; Ding, Lin; Yang, Zhen; Qiu,Huiying; Sun, Aining; Chen, Suning (*); Wu, Depei (*)；Allogeneic hematopoietic stem cell transplantation could improve survival of cytogenetically normal adult acute myeloid leukemia patients with DNMT3A mutations;AMERICAN JOURNAL OF HEMATOLOGY, 2015.11, 90(11): 992~997
(21) Xiaolin Ma(#) ; Lijun Wen; Lili Wu; Qingrong Wang; Hong Yao; Qian Wang;Liang Ma; Suning Chen (*), C Rare occurrence of a STAT5B N642H mutation in adult T-cell acute lymphoblastic leukemia;ancer Genetics, 2015.1, 208(1–2):52~53
(22) Wenjuan Ma(#) ; Jian Liu(#) ; Jundan Xie (#); Xiuyan Zhang; Haixia Zhou;Hong Yao; Weiqi Zhan; Dawei Guo; Lingying Zhu; Lun Xiao; Depei Wu; Haiyan Xu;Suning Chen (*); Yun Zhao(*)；Modulating the Growth and Imatinib Sensitivity of Chronic Myeloid Leukemia Stem/Progenitor Cells with Pullulan/MicroRNA Nanoparticles In Vitro, Journal of Biomedical Nanotechnology, 2015.1.1, 11:1961~1974
(23) Shen, Hongjie(#) ; Chao, Hongying; Ding, Zixuan; Feng, Yufeng; Cen,Jiannong; Pan, Jinlan; He, Jun; Zhou, Ming; Chen, Zixing; Chen, Suning (*),CALR and ASXL1 mutation analysis in 190 patients with essential thrombocythemia.Leuk Lymphoma, 2015.5, 56(3): 820~822
(24) Wu L(#) ; Xu Y (#); Wang Q; Ruan C; Drexler HG; Wu D; Macleod RA;Chen s(*)；High frequency of cryptic chromosomal rearrangements involving the LMO2 gene in T-cell acute lymphoblastic;Haematologica, 2015.6, 100(6): E233~E236
(25) Lijun Wen(#) ; Jing Xia(#) ; Qinrong Wang; Hong Yao; Jundan Xie; Jinlan Pan; Yongquan Xue; Depei Wu; Suning Chen (*)；Prognostic impact of residual normal metaphases in acute myeloid leukemia with t(8;21)(q22;q22), Int J Hematol, 2015.8, 102(2): 205~210
(26) Wenxiu Cheng(#) ; Xiaofei Yan; Nana Ping; Suning Chen (*); Aining Sun(*)；A case of acute erythroleukemia with concurrence of BCR-ABL and FLT3-TKD（D835E）mutation, LEUKEMIA & LYMPHOMA , 2015.8, 56(8): 2463~2464
(27) Hong Yao(#) ; Jinlan Pan; Chunxiao Wu; Hongjie Shen; Jundan Xie; Qinrong Wang; Lijun Wen; Qian Wang; Liang Ma; Lili Wu; Yun Zhao; Aining Sun(*) ;Suning Chen (*),Transcriptome sequencing reveals CHD1 as a novel fusion partner of RUNX1 in acute myeloid leukemia with t(5;21)(q21;q22), Molecular Cancer, 2015.4, 14
(28) Wenjuan Wang(#) ; Qian Wang; Tingting Tao; Aining Sun; Changgeng Ruan;Suning Chen(*) ,Identification of Two Novel b-Thalassemia Mutations (HBB:c.335-346del and HBB: c.108 C4G) in Han Chinese, Informa Healthcare, 2015.10,39(5): 359~61(44) Wang, Qinrong(#) ; Dong, Shasha(#) ; Yao, Hong; Wen, Lijun; Qiu, Huiying;Qin, Llili; Ma, Liang; Chen, Suning(*) , Rare Occurrence of the JAK1 Mutation in Acute Promyelocytic Leukemia Patients Haematologica, 2014.10.1, 99(10):E176~E178
(29) Jundan Xie(#) ; Qian Wang; Qinrong Wang; Hong Yao; Lijun Wen; Liang Ma;Depei Wu; Suning Chen (*),High frequency of BTG1 deletions in patients with BCR-ABL1–positive acute leukemia;Cancer Genetics, 2014.5, 207(5): 226~230
(30) Wang Xiuli(#); Dai Haiping (#) ; Wang Qian; Wang Qinrong; Xu Yang; Wang Ying; Su Aining; Ruan Jia; Chen Suning (*); Wu Depei(*) , EZH2 mutations are related to low blast percentage in bone marrow and -7/del(7q) in de novo acute myeloid leukemia. PLos One, 2013.4.21, 8(4)
(31) Yin, Jia(#) ; Xu, Yang(#) ; Pan, Jinlan; Wu, Chunxiao; Wang, Qinrong; Yao,Hong; Wen, Lijun; Tian, Xiaopeng; Wu, Depei; Sun, Aining (*)；Chen, Suning(*)；A BCR-JAK2 fusion gene from ins(22;9)(q11;p13p24) in a patient with atypical chronic myeloid leukemia , Acta Haematologica, 2013, 130(4): 251~253
(32) Cheng, Jijun (#); Guo, Shangqin(#)(*);Chen, Suning(#)；Mastriano, Stephen； J.; Liu, Chaochun; D'Alessio, Ana C.; Hysolli, Eriona; Guo, Yanwen; Yao,Hong; Megyola, Cynthia M.; Li, Dan; Liu, Jun; Pan, Wen; Roden, Christine A.;Zhou, Xiao-Ling; Heydari, Kartoosh; Chen, Jianjun; Park, In-Hyun; Ding, Ye;Zhang, Yi; Lu, Jun (*), An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis , Cell Reports, 2013.10,ell Reports, 2013.10, 5(2): 471~481
3、学术奖励
(1) 陈苏宁(3/10), 恶性血液肿瘤关键诊疗技术的创新和推广应用, 国务院, 科技进步, 国家二等奖, 2016.12.21
(2) 陈苏宁(3/11), 恶性血液肿瘤个体化治疗新策略的建立和推广, 江苏省人民政府,科技进步, 省部一等奖, 2016.2.19
(3) 陈苏宁(3/11), 恶性血液肿瘤诊疗关键技术的创新和推广, 教育部, 科技进步,省部一等奖, 2016.2.26
(4) 陈苏宁(2/10), 造血干细胞移植治疗恶性血液肿瘤关键技术的优化和推广, 中华医学会, 科技进步, 其他, 2015.12.21
(5) 陈苏宁(2/9), 造血干细胞移植治疗恶性血液肿瘤关键技术的优化和推广, 江苏省医学会, 科技进步, 其他, 2015.12.30
(6) 陈苏宁(3/9), 白血病中新的染色体异常、融合基因和白血病细胞系的研究, 江苏省人民政府, 科技进步, 省部一等奖, 2010.1.4
(7) 陈苏宁(1/1), 伴有t(6;11)(q27;q23)易位的裸小鼠高致瘤性人单核细胞白血病细胞系SHI-1的建立和鉴定, 全国优秀博士学位论文提名奖, 教育部, 自然科学, 2005
五、主持或参加科研项目（课题）及人才计划项目情况：
1.江苏省教育厅“江苏特聘教授”人才项目,江苏特聘教授,2017/月份-2019/月份,100万元,在研,主持
2.国家重点研发计划项目子课题,2016YFC0902803,白血病精准分子分型及个体化治疗临床体系建立,2016/07-2018/12,在研,主持
3.江苏省科技支撑计划重点项目,BE2015639, 骨髓增生异常综合征的规范化诊疗,2015/07-2018/06, 200万元, 在研, 主持
4.国家自然科学基金面上项目,81570139, NUP98重排白血病的致病机制研究,2016/01-2019/12, 55万元, 在研, 主持
5.国家自然科学基金面上项目,81070416,t(16;21)(p11;q22)/FUS-ERG融合基因相关急性白血病的生物学特征及发病机制研究,2011/01-2013/12,35万元,已结题,主持
6.国家863计划子项目,2013AA020202, 新一代高性能五分类血细胞分析系统研制, 2013/01-2015/12, 48万元, 已结题, 主持
7.江苏省自然基金委杰出青年基金项目, BK2012006, PAX5新融合基因的克隆和致白血病机制研究,2012/07-2015/06, 100万元, 已结题, 主持
8.国家973计划子课题, 2011CB933501, 纳米材料在血细胞研究中的应用, 2011/01-2015/12, 100万元, 已结题, 主持
9.美国白血病淋巴瘤协会和国际华氏巨球蛋白血症基金会国际项目，Establishment and characterization of novel Waldenstr?m's Macroglobulinemia cell lines,2010/06-2013/05,20万美元,已结题,主持
六、授权发明专利
无
七、获得学术奖励
(1) 陈苏宁(3/10), 恶性血液肿瘤关键诊疗技术的创新和推广应用, 国务院, 科技进步, 国家二等奖, 2016.12.21
(2) 陈苏宁(3/11), 恶性血液肿瘤个体化治疗新策略的建立和推广, 江苏省人民政府,科技进步, 省部一等奖, 2016.2.19
(3) 陈苏宁(3/11), 恶性血液肿瘤诊疗关键技术的创新和推广, 教育部, 科技进步,省部一等奖, 2016.2.26
(4) 陈苏宁(2/10), 造血干细胞移植治疗恶性血液肿瘤关键技术的优化和推广, 中华医学会, 科技进步, 其他, 2015.12.21
(5) 陈苏宁(2/9), 造血干细胞移植治疗恶性血液肿瘤关键技术的优化和推广, 江苏省医学会, 科技进步, 其他, 2015.12.30
(6) 陈苏宁(3/9), 白血病中新的染色体异常、融合基因和白血病细胞系的研究, 江苏省人民政府, 科技进步, 省部一等奖, 2010.1.4
(7) 陈苏宁(1/1), 伴有t(6;11)(q27;q23)易位的裸小鼠高致瘤性人单核细胞白血病细胞系SHI-1的建立和鉴定, 全国优秀博士学位论文提名奖, 教育部, 自然科学, 2005